Published in 2009, Signature in the Cell: DNA and the Evidence for Intelligent Design (SITC) is recognized as establishing one of the strongest pillars underlying the argument for intelligent design. To call the book fascinating and important is an understatement. No less interesting in its way, however, was the critical response and it is with that this book is concerned. For the fact is that despite SITC being written about in print and online by numerous friends and foes of intelligent-design theory, few—if any—of the critics really grappled with the substance of Meyer’s argument. This is remarkable and telling. In this digital book which includes live links to the critics’ own writings, defenders of SITC analyze the hostile response.